Alzheimer Disease candidate variants are associated with cerebral amyloid angiopathy

Journal article

D. Godrich, Jeremy Pasteris, E. Martin, G. Schellenberg, M. Pericak-Vance, M. Cuccaro, W. Scott, W. Kukull, T. Montine, G. Beecham
Alzheimer's & Dementia, 2022

Semantic Scholar DOI

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APA Click to copy
Godrich, D., Pasteris, J., Martin, E., Schellenberg, G., Pericak-Vance, M., Cuccaro, M., … Beecham, G. (2022). Alzheimer Disease candidate variants are associated with cerebral amyloid angiopathy. Alzheimer's &Amp;Amp; Dementia.

Chicago/Turabian Click to copy
Godrich, D., Jeremy Pasteris, E. Martin, G. Schellenberg, M. Pericak-Vance, M. Cuccaro, W. Scott, W. Kukull, T. Montine, and G. Beecham. “Alzheimer Disease Candidate Variants Are Associated with Cerebral Amyloid Angiopathy.” Alzheimer's & Dementia (2022).

MLA Click to copy
Godrich, D., et al. “Alzheimer Disease Candidate Variants Are Associated with Cerebral Amyloid Angiopathy.” Alzheimer's &Amp;Amp; Dementia, 2022.

BibTeX Click to copy

@article{d2022a,
  title = {Alzheimer Disease candidate variants are associated with cerebral amyloid angiopathy},
  year = {2022},
  journal = {Alzheimer's &amp; Dementia},
  author = {Godrich, D. and Pasteris, Jeremy and Martin, E. and Schellenberg, G. and Pericak-Vance, M. and Cuccaro, M. and Scott, W. and Kukull, W. and Montine, T. and Beecham, G.}
}

Abstract

The hallmark lesions of Alzheimer Disease (AD) include tangles and plaques; however, these seldom appear alone. Lesions of AD‐related dementias such as vascular dementias and Lewy body dementias often co‐occur with AD. These co‐occurring lesions and total lesion burden are associated with a higher likelihood of dementia and severe cognitive impairment. Even amongst other lesions, cerebral amyloid angiopathy (CAA) presents a strong risk for more severe cognitive impairment. CAA also shows moderate correlations to AD (rho = 0.31), suggesting that CAA pathology could present an underlying or related process of AD pathology. We hypothesize that there is a genetic overlap between CAA and AD and therefore we investigate the influence of known AD genes on CAA.