Journal article
D. Godrich, P. Richeson, G. Schellenberg, W. Scott, T. Montine, G. Beecham
Alzheimer's & Dementia, 2021
Alzheimer's & Dementia, 2021
Semantic Scholar
DOI
PubMed
Cite
Cite
APA
Click to copy
Godrich, D., Richeson, P., Schellenberg, G., Scott, W., Montine, T., & Beecham, G. (2021). Neuropathologic lesions and comorbidity in Alzheimer disease and related dementias in a heterogeneous clinical population. Alzheimer's &Amp; Dementia.
Chicago/Turabian
Click to copy
Godrich, D., P. Richeson, G. Schellenberg, W. Scott, T. Montine, and G. Beecham. “Neuropathologic Lesions and Comorbidity in Alzheimer Disease and Related Dementias in a Heterogeneous Clinical Population.” Alzheimer's & Dementia (2021).
MLA
Click to copy
Godrich, D., et al. “Neuropathologic Lesions and Comorbidity in Alzheimer Disease and Related Dementias in a Heterogeneous Clinical Population.” Alzheimer's &Amp; Dementia, 2021.
BibTeX Click to copy
@article{d2021a,
title = {Neuropathologic lesions and comorbidity in Alzheimer disease and related dementias in a heterogeneous clinical population},
year = {2021},
journal = {Alzheimer's & Dementia},
author = {Godrich, D. and Richeson, P. and Schellenberg, G. and Scott, W. and Montine, T. and Beecham, G.}
}
Abstract
Alzheimer disease (AD) is the most common cause of dementia. Upon autopsy, most dementia patients display the core AD brain lesions: neurofibrillary tangles (NFTs), neuritic plaques (NPs), and diffuse plaques (DPs). Often, patients display other non‐AD lesions: Lewy bodies (LBs), cerebral amyloid angiopathy (CAA), arteriolosclerosis, hippocampal sclerosis (HS), and vascular brain injury (VBI). Previous population‐based studies suggest that dementia of mixed pathologies is present common and associated with more severe cognitive impairment. Here, we report on the generalizability of these findings in a more heterogeneous clinic‐based group and describe the contribution of individual lesions and lesion comorbidity to severity and progression of dementia.
